Did you know that approximately 5 to 10 percent of all cancers are hereditary? Have you had any genetic testing to identify the hereditary risk of cancer? At Moffitt Cancer Center, we emphasize that early detection saves lives. That’s why our specialty GeneHome Clinic is dedicated to evaluating and serving individuals who have cancer predispositions, allowing our patients to take appropriate steps to prevent cancer and enjoy life with less uncertainty about their health.
The geneticists and other genetic professionals in GeneHome provide expert consultation and coordinated cancer screening services related to all cancer-related gene mutations. If you test positive for a gene mutation, our specialists can help you plan an appropriate cancer screening schedule and preventive strategies, conduct a comprehensive health review and physical examination, prescribe screening tests, refer you to proper cancer specialists and make important educational and counseling services available to you and your family regarding your potential health risks. Your screening, prevention and treatment can also be carried out in a cancer center that is preferred by you and your primary physician, so you won’t need to travel to multiple, unfamiliar centers to receive the services you need.
Comprehensive and coordinated genetic cancer care
GeneHome serves as a “home base” for Moffitt’s cancer specialists and other health care providers, helping to ensure a seamless exchange of genetic information and well-rounded medical services for our patients who carry a cancer gene mutation.
Here are a few examples of the hereditary cancer risk syndromes and cancer genes that can be evaluated and managed in GeneHome:
- Hereditary breast and ovarian cancer syndrome (BRCA1 and BRCA2 genes)
- Li-Fraumeni syndrome (TP53 gene)
- Cowden syndrome (PTEN gene)
- Lynch syndrome (MLH1, MSH2, MSH6 and PMS2 genes)
- Hereditary paraganglioma and pheochromocytoma (SDHA, SDHAF2, SDHB, SDHC, SDHD, MAX, TMEM127 genes)
- Colon and gastrointestinal polyposis (APC and MUTYH genes)
- Hereditary leiomyomatosis and renal cell cancer (FH gene)
- Hereditary diffuse gastric cancer syndrome (CDH1 gene)
- Multiple endocrine neoplasia (MEN1 and RET gene)
- Familial atypical multiple moles and melanoma syndrome (CDKN2A gene)
- Peutz-Jeghers syndrome (STK11 gene)
- Neurofibromatosis type 1 (NF1 gene)
- Neurofibromatosis type 2 (NF2 gene)
- Schwannomatosis (SMARCB1 and LZTR1 genes)
- Fanconi Anemia
- Ovarian Cancer
- Juvenile polyposis syndrome (BMPR1A and SMAD4)
- Birt-Hogg-Dube syndrome (FLCN gene)
- Von Hippel-Lindau syndrome (VHL gene)
- Tuberous sclerosis complex (TSC1 or TSC2 gene)
- BAP1 tumor predisposition syndrome (BAP1 gene)
- Gorlin Syndromes (PTCH1 gene)
- DICER1 syndrome
- Prostate Cancer (HOXB13 gene included)
- Retinoblastoma (RB1 gene)
- CHEK2, ATM genes
Knowledge is powerful. If you have a hereditary risk for cancer, request an appointment with GeneHome at Moffitt by calling 813-745-8123 or emailing our team at Genehome@Moffitt.org to gain invaluable insight regarding your health.