Brain Cancer Clinical Trials

clinical trials

Moffitt Cancer Center’s Neuro-Oncology Program is actively working to improve treatment options, outcomes and quality of life for brain cancer patients now and into the future through our nationally renowned clinical trial program. Before novel treatments are made widely available, they must go through clinical trials that allow researchers to identify when they are most effective, how they interact with other therapies and their success against various types of brain cancer. Advances in understanding the biology of cancer, and efforts to develop new, more effective therapeutics, ultimately result in the development of novel treatments.

What are brain cancer clinical trials?

Clinical trials are controlled medical studies that are used to assess the effectiveness of innovative treatment options. Physicians and scientists are frequently exploring new therapies, such as chemotherapy combinations, biologic therapies and vaccines. Today’s most widely used brain cancer treatments were once evaluated in clinical trials.

Brain cancer clinical trials at Moffitt

Moffitt spearheads one of the largest cancer clinical trial programs in the nation. Clinical trials within our brain cancer program include investigations into:

  • New ways to use immunotherapy to fight brain cancer
  • Gene therapy for brain cancer
  • Treatment of leptomeningeal disease (LMD), which currently has few effective treatments
  • Use of personalized approaches to match the treatment to the genetics of a patient’s tumor
  • Direct delivery of novel therapeutics to tumor tissue
  • Imaging techniques
  • Immunotherapies
  • Radiation therapies
  • Vaccine therapies
  • Brain metastases diagnostics and treatments
  • Neurologic complications of cancers (neuropathies or paraneoplastic syndromes) and its therapies (immunologic therapies, CAR-T therapies, etc.)

Why choose Moffitt?

Research and clinical trials raise the standard of cancer care and continue to bring us closer to a cure. Thanks to Moffitt’s robust clinical trial program and ongoing research efforts, we have been awarded multiple research grants and are recognized as a Comprehensive Cancer Center by the National Cancer Institute. We are currently the only cancer center based in Florida to hold this prestigious designation. Furthermore, our team includes specialists who focus exclusively on brain cancer (primary brain tumors, brain metastases and leptomeningeal disease) and improving treatment options for these diseases, allowing our patients to receive care under the supervision of uniquely experienced professionals.

The decision to participate in a clinical trial is a highly personal one that requires careful consideration. If you would like to receive more information about brain cancer clinical trials at Moffitt and whether or not you are a candidate, contact 1-813-745-6100 or 1-800-679-0775 (toll-free) to speak with a knowledgeable clinical navigator. You may also submit a clinical trials inquiry form online at your convenience.

Medically Reviewed by Dr. Michael Vogelbaum, Program Leader, Department of Neuro-Oncology.

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Open Clinical Trials:

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CLINICAL TRIAL 18752

ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 18778

A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19327

A Phase 2 Trial of Pembrolizumab Plus Bevacizumab in Patients with Metastatic Melanoma or Non-small Cell Lung Cancer with Untreated Brain Metastases

Disease Site: Brain and Nervous System, Lung, Melanoma, skin, Melanoma, Non small cell lung cancer

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CLINICAL TRIAL 19648

Phase IB Study of Avelumab with Radiotherapy in Patients with Leptomeningeal Disease

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19956

A Phase 1b Trial of CB-839 in Combination with Radiation Therapy and Temozolomide in Patients with IDH-mutated Diffuse Astrocytoma and Anaplastic Astrocytoma

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19970

A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20110

GBM Agile: Global Adaptive Trial Master Protocol

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20145

A Pilot Study of Intratumorally and Intraparenchymally Administered OS2966 using Convection-enhanced Delivery in Patients with Recurrent/Progressive High-grade Glioma Undergoing a Clinically-indicated Surgical Resection

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20347

A phase 2 basket trial of glutaminase inhibitor (BeGIN) CB-839 HCl in patients with NF1 Aberrations, NF1 mutant malignant peripheral nerve sheath tumors (MPNST), KEAP1/NRF2 and LKB1 Aberrant tumors

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20487

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast

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CLINICAL TRIAL 20637

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19731

Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System, Brain & nervous system

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CLINICAL TRIAL 20022

Feasibility Study for Electroacupuncture for Chemotherapy- Induced Peripheral Neuropathy (CIPN) Using a Point-Of-Nerve Conduction Device (NeuroMetrix) and the Rydel-Seiffer Tuning Fork

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20015

Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma

Disease Site: Brain and Nervous System, Brain & nervous system

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CLINICAL TRIAL 50337

Optimization of High-Grade Glioma Tissue Dissociation for the Maintenance of Cell Viability

Disease Site: Brain and Nervous System, Brain & nervous system

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