Breast Cancer Clinical Trials

Breast Cancer  patient speaks with her physician about Clinical Trials St Petersburg FL

Breast cancer clinical trials offer new ways to treat breast cancer and enhance patient outcomes. As a recognized leader in the development of scientific advances for preventing, diagnosing and treating breast cancer, Moffitt Cancer Center is continually performing groundbreaking research, lead by the Breast Program Research Director Dr. Heather Han, who is also a medical oncologist specializing in breast cancer. Our research initiatives allow us to offer our patients a wide range of treatment options, including a variety of clinical trials.

 

 

The Importance of Clinical Trials

These promising studies comprise a long and meticulous research process that begins in a laboratory and progresses through an extensive, multi-step testing procedure before being made available to the general public. They help to develop new standards for treatment and allow doctors and researchers to have a broader understanding of diseases and how to treat them. Clinical trials can also help doctors find new ways to diagnose certain conditions and how individuals can reduce their chances of developing them.

Breast Cancer Clinical Trials at Moffitt

At Moffitt, the health and safety of our patients is always our top priority. Patients are carefully selected for participation in breast cancer clinical trials. Even if one or more research studies are available to treat a patient’s specific type of cancer, the patient may or may not qualify based on a number of factors, such as:

  • Age
  • Gender
  • Cancer stage
  • Overall health and wellness
  • Other health conditions
  • Past cancer treatments

If a patient is deemed eligible for a clinical trial, the decision on whether to participate is highly personal and should be made with the guidance of a physician. During a consultation, a physician will generally discuss the treatment, explain what can be expected to happen and describe the care the patient will receive. The patient will be invited to ask specific questions, such as how the study might affect his or her everyday life.

Breast cancer clinical trials can require a patient to undergo additional tests, see a physician more often and mandate more of the patient’s time. For these reasons, participants are required to sign informed consent forms to confirm that they were provided with all of the facts prior to deciding to take part in a study. Many clinical trial participants feel that the quality of care and attention that they receive are well worth the extra time and other commitments. 

To learn more about the breast cancer clinical trials currently available at Moffitt, contact us at 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form. We welcome patients with or without a referral.

 

Helpful Links:

Click Here to View Clinical Trials

 

 

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Open Clinical Trials:

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CLINICAL TRIAL 18356

A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients who have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy

Disease Site: Breast - Female

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CLINICAL TRIAL 18979

Phase II Open-Label, Randomized Study of PARP inhibition (Olaparib) Either Alone or in Combination with Anti-PD-L1 Therapy (Atezolizumab; MPDL3280A) in Homologous DNA Repair (HDR) Deficient, Locally Advanced or Metastatic Non-HER2-positive Breast Cancer

Disease Site: Breast - Male, Breast - Female

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CLINICAL TRIAL 19117

A Multicenter Phase II Study of Vaccines to Prevent Recurrence in Patients with HER-2 Positive Breast Cancer

Disease Site: Breast - Female

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CLINICAL TRIAL 19337

A Pilot Study Utilizing a HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+ Breast Cancer

Disease Site: Breast - Female, Breast - Male

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CLINICAL TRIAL 19480

The Reveal Study: A Phase 1/2, Open-Label, Multicenter, Dose Escalation And Dose Expansion Study Of Nktr-262 In Combination With Bempegaldesleukin (Nktr-214) And In combination With Bempegaldesleukin (Nktr-214) Plus Nivolumab In Patients With Locally Advanced Or Metastatic Solid Tumor Malignancies

Disease Site: Any Site, Bones and Joints, Breast, Colon, Corpus Uteri, Eye and Orbit, Lung, Melanoma, Skin - Do Not Use, Ovary, Soft Tissue, Urinary Bladder

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CLINICAL TRIAL 19646

Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients with Metastatic HER-2+ Breast Cancer, Phase III

Disease Site: Breast - Female, Breast Cancer

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CLINICAL TRIAL 20030

A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node or T3N0 Positive Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 20132

Phase 1/2 Dose-Escalation and Expansion Study of FLX475 Alone and in Combination with Pembrolizumab in Advanced Cancer

Disease Site: Lip, Oral Cavity and Pharynx, Any Site, Breast

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CLINICAL TRIAL 20159

A Phase 1 Study of ZW49 in Patients with Locally Advanced (Unresectable) or Metastatic HER2-Expressing Cancers

Disease Site: Esophagus, Breast - Female, Breast Cancer, Esophageal (Throat)

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CLINICAL TRIAL 20171

A Phase 1/2, Open-label, Dose Escalation, and Cohort Expansion Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of ARV-471 in Patients with ER+/HER2- Locally Advanced or Metastatic Breast Cancer, Who Have Received Prior Hormonal Therapy and Chemotherapy in the Locally Advanced/Metastatic Setting

Disease Site: Breast - Female, Breast - Male

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CLINICAL TRIAL 20173

A Phase 2, Multi-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of IPI-549 Administered in Combination with Front-line Treatment Regimens in Patients with Locally Advanced and/or Metastatic Triple-Negative Breast Cancer or Renal Cell Carcinoma

Disease Site: Breast - Female, Breast - Male, Breast Cancer

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CLINICAL TRIAL 20174

A Phase I, Open-Label, Dose Finding Study To Assess The Safety, Tolerability, Pharmacokinetics, And Preliminary Efficacy Of OBT076, A CD205-Directed Antibody-Drug Conjugate, In Recurrent And/Or Metastatic CD205 Positive Solid Tumors And In Women With CD205 Positive HER2-Negative Metastatic Breast Cancer

Disease Site: Any Site, Breast Cancer

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CLINICAL TRIAL 20349

A Phase 2 Study of TAS-120 in Metastatic Breast Cancers Harboring Fibroblast Growth Factor Receptor (FGFR) Amplifications

Disease Site: Breast

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CLINICAL TRIAL 20487

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast

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CLINICAL TRIAL 20499

Pivotal Study of the Lum Imaging System For Assisting Intraoperative Detection of Residual Cancer in the Tumor Bed of Female Patient with Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 20615

A Phase 1 Open-Label, Multi-Center First in Human Study of TnMUC1-Targeted Genetically-Modified Chimeric Antigen Receptor T Cells in Patients with Advanced TnMUC1-Positive Solid Tumors and Multiple Myeloma

Disease Site: Breast, Lung, Multiple Myeloma, Ovary, Pancreas

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CLINICAL TRIAL 20619

A Phase 2 Multicenter, Open-label Study of Rucaparib as Treatment for Solid Tumors Associated with Deleterious Mutations in Homologous Recombination Repair Genes (LODESTAR)

Disease Site: Breast Cancer, Gastrointestinal, Lung, Unknown Sites, Reproductive System

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CLINICAL TRIAL 20631

Randomized Prospective Trial of Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 20730

Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination with Ado-Trastuzumab Emtansine (T-DM1) for Subjects with Unresectable Locally-Advanced or Metastatic HER2+ Breast Cancer (HER2CLIMB-02)

Disease Site: Breast

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CLINICAL TRIAL 20851

A Phase 1, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Combinations of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Subjects with Locally Advanced or Metastatic Solid Tumors

Disease Site: Breast

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CLINICAL TRIAL 16933

Older Breast Cancer Patients: Risk For Cognitive Decline

Disease Site: Breast - Female, Breast Cancer

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CLINICAL TRIAL 19209

Combined Imaging and Blood Biomarkers for Breast Cancer Diagnosis

Disease Site: Breast - Female, Breast Cancer

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CLINICAL TRIAL 20479

Efficacy of SOAR (Survivors Overcoming and Achieving Resiliency) Survivorship Workshop for Breast Cancer Survivors

Disease Site: Breast

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CLINICAL TRIAL 19733

Motivating a Spectrum of Cancer Patients to Quit Smoking: Intervention Development and Feasibility

Disease Site: Rectum, Other Female Genital, Urinary Bladder, Breast, Colon, Melanoma, skin, Bladder, Breast Cancer, Colorectal, Melanoma, Ovarian, Uterus, Vaginal, Vulva

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