Head and Neck Cancer Clinical Trials

Head and neck cancer clinical trials are important research studies designed to evaluate the effectiveness of promising new therapies in comparison to the currently available options. The goal is to find better ways to treat cancer – and ultimately find a cure – while enhancing patient quality of life. All new treatment options are evaluated in this way; in fact, the current standard of care was once available only through clinical trials.

As a recognized leader in performing groundbreaking cancer research, Moffitt Cancer Center has a nationally acclaimed clinical trials program with active protocols for various types of head and neck cancer. For instance, our researchers are studying:

  • New surgical techniques
  • New radiation delivery methods
  • New chemotherapy drugs, drug combinations and dosages
  • Emerging treatments, such as gene therapy
  • New ways to prevent cancer recurrence

Patients who take part in clinical trials can not only contribute to the existing knowledge base to help all current and future cancer patients, but also benefit personally by being closely monitored by a team of cancer experts as they receive either the current standard of care or new treatments that are unavailable elsewhere.

Patients who turn to Moffitt for head or neck cancer treatment can feel confident that they will receive the most effective treatment options available – whether or not they choose to participate in clinical trials. Our multispecialty team of experts emphasizes a bench-to-bedside approach, incorporating the latest laboratory findings into every patient’s unique treatment plan. 

View Head and Neck Clinical Trials

If you’d like to learn more about head and neck cancer clinical trials at Moffitt, call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form online. No referrals are required.

 

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Open Clinical Trials:

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CLINICAL TRIAL 18994

Phase II Randomized Trial of Radiotherapy with or without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) with TP53 Sequencing

Disease Site: Lip, Oral Cavity and Pharynx, Larynx, Head & Neck

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CLINICAL TRIAL 19473

Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin

Disease Site: Other Endocrine System, Head & Neck

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CLINICAL TRIAL 19570

A Phase II Trial of Pembrolizumab and Cabozantinib in Patients with RM SCCHN

Disease Site: Other Endocrine System, Head & Neck

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CLINICAL TRIAL 19748

Phase II Randomized Trial of Radiotherapy with Concurrent and Adjuvant Pembrolizumab (Keytruda®) Versus Concurrent Chemotherapy in Patients with Advanced/Intermediate-Risk p16+ Head and Neck Squamous Cell Carcinoma (KEYCHAIN Trial)

Disease Site: Lip, Oral Cavity and Pharynx, Other Skin, Head & Neck, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 19855

The AIM-HN and SEQ-HN Study: A 2 Cohort, Non-comparative, Pivotal Study Evaluating the Efficacy of Tipifarnib in Patients with Head and Neck Squamous Cell Carcinoma(HNSCC) with HRAS Mutations (AIM-HN) and the Impact of HRAS Mutations on Response to First Line Systemic Therapies for HNSCC (SEQ-HN)

Disease Site: Lip, Oral Cavity and Pharynx, Larynx, Head & Neck, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20114

A Single Arm Phase II Study of Cemiplimab-rwlc in Immunocompromised Patients with Unresectable Locally Recurrent and/or Metastatic Cutaneous Squamous Cell Carcinoma (CSCC)

Disease Site: Other Head & Neck, Other Skin, Skin, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20144

A Phase 1, First-in-Human, Open-Label, Dose Escalation and Expansion Study of CUE-101 Monotherapy in Second Line and CUE-101 Combination Therapy with Pembrolizumab in First Line Patients with HPV16+ Recurrent / Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20485

A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment

Disease Site: Any Site, Head & Neck, Larynx, Mouth, lip, nasal cavity, Throat

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CLINICAL TRIAL 20845

Health Insurance Literacy in Head and Neck Cancer Patients

Disease Site: Esophageal (Throat), Head & Neck, Larynx, Lip, Oral Cavity and Pharynx, Mouth, lip, nasal cavity, Pharynx

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CLINICAL TRIAL 21079

Head and Neck Cancer Pre-Surgery Education and Discharge Planning: Key Stakeholder Perceptions

Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx

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