Lung Cancer Clinical Trials

Clinical trials play an important role in lung cancer treatment. After a promising new drug or therapy is identified and extensively tested to ensure its safety, clinical trials are conducted to determine its effectiveness in relation to the other treatments that are currently available. All emerging treatments go through this process; even the treatments that are now considered the “gold standard” in cancer care were once only available through clinical trials.

At Moffitt Cancer Center, we have a robust program that focuses exclusively on lung cancer clinical trials. Our trials explore treatments such as:

Our Lung Cancer Program has an extensive team of clinical trial coordinators, research data specialists and other medical professionals.
  • Chemotherapy drugs and combinations
  • Immunotherapy
  • Gene therapy
  • Targeted therapy

Clinical trials are a large part of what we do at Moffitt Cancer Center.

Through our efforts, we’ve compiled one of the largest existing outcomes databases in the nation, which contains more than 13 years of trial results.

Moffitt’s lung cancer research program has been awarded multiple grants by the National Cancer Institute. We have also been named a Comprehensive Cancer Center due to our ability to apply the findings of our research to our patients’ individualized treatment plans. At Moffitt, our trials don’t just benefit the patients who participate; they benefit every future patient whose lives are impacted by lung cancer.

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Medically reviewed by Dr. Andreas Saltos.

To learn more about the available lung cancer clinical trials at Moffitt Cancer Center, call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form. We don’t require a referral for consultation, and we’ll help you determine if you qualify for one of our trials.

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Open Clinical Trials:

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CLINICAL TRIAL 17970

A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

Disease Site: Lung

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CLINICAL TRIAL 18304

A Phase II Trial of AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer

Disease Site: Lung

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CLINICAL TRIAL 18494

A Phase I/II Study of Pembrolizumab and Vorinostat in Patients with Immune Therapy Naïve and Immune Therapy Pretreated Stage IV NSCLC

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 19327

A Phase 2 Trial of Pembrolizumab Plus Bevacizumab in Patients with Metastatic Melanoma or Non-small Cell Lung Cancer with Untreated Brain Metastases

Disease Site: Brain and Nervous System, Lung, Melanoma, skin, Melanoma, Non small cell lung cancer

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CLINICAL TRIAL 19387

A Phase 2 Study of Poziotinib in Patients with Non-Small Cell Lung Cancer, (NSCLC), Locally Advanced or Metastatic, with EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20)

Disease Site: Lung

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CLINICAL TRIAL 19389

A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of JNJ-61186372, a Human Bispecific EGFR and cMet Antibody, in Subjects with Advanced Non-Small Cell Lung Cancer

Disease Site: Lung

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CLINICAL TRIAL 19406

Phase I/II Study of Nivolumab and Ipilimumab combined with Nintedanib in Non Small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 19480

The Reveal Study: A Phase 1/2, Open-Label, Multicenter, Dose Escalation And Dose Expansion Study Of Nktr-262 In Combination With Bempegaldesleukin (Nktr-214) And In combination With Bempegaldesleukin (Nktr-214) Plus Nivolumab In Patients With Locally Advanced Or Metastatic Solid Tumor Malignancies

Disease Site: Any Site, Bones and Joints, Breast, Colon, Corpus Uteri, Eye and Orbit, Lung, Melanoma, Skin - Do Not Use, Ovary, Soft Tissue, Urinary Bladder

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CLINICAL TRIAL 19656

Phase I Study of Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLC

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 19683

A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of RMC-4630 Monotherapy in Adult Participants with Relapsed/Refractory Solid Tumors

Disease Site: Lung

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CLINICAL TRIAL 19684

A Phase I/Ib, Open-Label, Multi-Center Study of NZV930 as a Single Agent and in Combination with PDR001 and/or NIR178 in Patients with Advanced Malignancies

Disease Site: Lung

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CLINICAL TRIAL 19694

Phase II Study of Nivolumab and Ramucirumab for Patients with Previously-Treated Mesothelioma

Disease Site: Lung, Mesothelioma

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CLINICAL TRIAL 19936

Maintenance Systemic Therapy versus Local Consolidative Therapy (Lct) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (Nsclc): A Randomized Phase II/III Trial

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 19940

A Phase I/II Study of Nivolumab, Ipilimumab and Plinabulin in Patients with Recurrent Small Cell Lung Cancer: Big Ten Cancer Research Consortium BTCRC-LUN17-127

Disease Site: Lung, Small cell lung cancer

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CLINICAL TRIAL 19942

Sequential Maintenance with Thoracic Radiotherapy and Durvalumab (MEDI4736) monotherapy or Durvalumab (MEDI 4736) combinations (Tremelimumab or Olaparib) in patients with Extensive Stage-Small Cell Lung Cancer after first line Platinum-based Chemotherapy

Disease Site: Lung, Small cell lung cancer

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CLINICAL TRIAL 19948

A Phase 2 Study of Atezolizumab and Cobimetinib in PD-1/PD-L1 Inhibitor Resistant or Refractory Non-Small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20026

A Phase I Study of NBTXR3 Activated by Radiotherapy for Patients with Advanced Cancers Treated with an Anti-PD1 Therapy

Disease Site: Lung

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CLINICAL TRIAL 20078

A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA Non Small Cell Lung Cancer (NSCLC) (KEYNOTE-867)

Disease Site: Lung, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20099

A Phase 3 Study of Pembrolizumab in Combination with Carboplatin/Taxane (Paclitaxel or Nab-paclitaxel) Followed by Pembrolizumab with or without Maintenance Olaparib in the First-line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20163

EA5163/S1709 INSIGNA: A Randomized, Phase III Study of Firstline Immunotherapy alone or in Combination with Chemotherapy in Induction/Maintenance or Postprogression in Advanced Nonsquamous Non©\Small Cell Lung Cancer (NSCLC) with Immunobiomarker SIGNature©\driven Analysis

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20178

An Open-Label Randomized Phase II Study of Combining Osimertinib with and without Ramucirumab in TKI-naïve EGFR-mutant Locally Advanced or Metastatic NSCLC

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20270

A Phase 2, Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN-144 or LN-145) in Patients with Solid Tumors (IOV-COM-202)

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20304

A Phase 1/2, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 510 Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and AMG 510 Combination Therapy in Subjects With Advanced NSCLC With KRAS p.G12C Mutation (Codebreak 100)

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20332

Activity and Enhancement of Immune Checkpoint Inhibition with Lurbinectedin in Relapsed/Recurrent Small Cell Lung Cancer (SCLC)

Disease Site: Lung, Small cell lung cancer

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CLINICAL TRIAL 20348

Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III randomized study of chemoradiation versus chemoradiation plus Atezolizumab

Disease Site: Lung, Small cell lung cancer

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CLINICAL TRIAL 20364

A Phase 1/2 Study of REGN5093 in Patients with Met-Altered Advanced Non-Small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20373

TH-138: Phase II Randomized Trial of Carboplatin + Pemetrexed + Bevacizumab, With or Without Atezolizumab in Stage IV Non-Squamous NSCLC Patients who Harbor a Sensitizing EGFR Mutation or Have Never Smoked

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20402

A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy plus Nivolumab versus Neoadjuvant Chemotherapy plus Placebo, followed by Surgical Resection and Adjuvant Treatment with Nivolumab or Placebo for Participants with Resectable Stage II-IIIB Non-small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20474

A Phase 1b, First-in-Human, Dose Escalation and Expansion Study of XMT-1536 In Patients with Solid Tumors Likely to Express NaPi2b

Disease Site: Lung

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CLINICAL TRIAL 20577

A Phase 1b/2, Open-Label, Multicenter Dose-Escalation and Dose-Expansion Study of the Combination of RMC-4630 and Cobimetinib in Adult Participants with Relapsed/Refractory Solid Tumors with Specific Genomic Aberrations

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20579

Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Disease Site: Lung

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CLINICAL TRIAL 20605

A Phase 1b Efficacy and Safety Study of Cofetuzumab Pelidotin (ABBV-647, a PTK7-Targeting Antibody Drug Conjugate) in Subjects with PTK7-Expressing, Recurrent Non-Small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20615

A Phase 1 Open-Label, Multi-Center First in Human Study of TnMUC1-Targeted Genetically-Modified Chimeric Antigen Receptor T Cells in Patients with Advanced TnMUC1-Positive Solid Tumors and Multiple Myeloma

Disease Site: Breast, Lung, Multiple Myeloma, Ovary, Pancreas

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CLINICAL TRIAL 20619

A Phase 2 Multicenter, Open-label Study of Rucaparib as Treatment for Solid Tumors Associated with Deleterious Mutations in Homologous Recombination Repair Genes (LODESTAR)

Disease Site: Breast Cancer, Gastrointestinal, Lung, Unknown Sites, Reproductive System

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CLINICAL TRIAL 20720

S1827, MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Disease Site: Lung, Small cell lung cancer

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CLINICAL TRIAL 20722

Phase III Randomized Trial of Pleurectomy/Decortication plus Chemotherapy with or without Adjuvant Hemithoracic Intenstiy-Modulated Pleural Radiation Therapy (IMPRINT) for Malignant Pleural Mesothelioma (MPM)

Disease Site: Lung

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CLINICAL TRIAL 20826

S1701, A Randomized Phase II Trial of Carboplatin-Paclitaxel with or without Ramucirumab in Patients with Unresectable Locally Advanced, Recurrent, or Metastatic Thymic Carcinoma

Disease Site: Lung

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CLINICAL TRIAL 21030

A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression on or After Platinum-Based Chemotherapy in Combination with Checkpoint Inhibitor Therapy (SAPPHIRE)

Disease Site: Lung

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CLINICAL TRIAL 16480

Radiomics: A Prospective Study of Outcome in Lung Cancer

Disease Site: Lung

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CLINICAL TRIAL 17723

Expansion of Enduring Infrastructure to Support Lung Cancer Screening Research

Disease Site: Lung

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CLINICAL TRIAL 17971

Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

Disease Site: Lung

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CLINICAL TRIAL 19622

Phase II Trial of Investigational Agents to Modulate Intermediate Endpoint Biomarkers, Including Pulmonary Nodules, in Former and Current Smokers

Disease Site: Lung

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CLINICAL TRIAL 20003

LungMAP: A Master Protocol to Evaluate Biomarker-Driven Therapies And Immunotherapies In Previously-Treated Non-Small Cell Lung Cancer(Lung-MAP Screening Study)

Disease Site: Lung

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CLINICAL TRIAL 20528

Prospective, Interventional Pilot Study of Mobile Devices and Digital Applications to Detect Early Pneumonitis and Other Pulmonary Adverse Events in Unresectable Stage III Non-Small Cell Lung Cancer Patients on Durvalumab

Disease Site: Lung

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CLINICAL TRIAL 20925

Physician Adherence to Patient Safety Surveillance of Tyrosine Kinase Inhibitor Side Effects When Treating Non-Small Cell Lung Cancer

Disease Site: Lung

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