Cancer Type: Genitourinary
Study Type: Treatment
Phase: Phase II
Principal Investigator: Jain, Rohit
Cabozantinib plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma (PemCab)
Primary Objective: To evaluate measurable disease overall response rate (ORR). Secondary Objectives and Endpoints: - To evaluate progression-free survival (PFS) at 6 months (PFS6). - To evaluate Overall Survival (OS). - To evaluate toxicities associate with the combination treatment. Exploratory Objectives and Endpoints: - To evaluate molecular markers for pharmacodynamic pathways associated with response. - To evaluate ORR and PFS6 using immune specific disease assessment criteria
Immunotherapy; Therapy (NOS)
Cabozantinib (XL 184); Pembrolizumab (Keytruda)
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