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Clinical Trial 20372

Cancer Type: Malignant Hematology
Study Type: Other
NCT#: NCT04319237

Phase: N/A
Principal Investigator: Jim, Heather

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Study Title

Axicabtagene Ciloleucel:Neurocognitive and Patient-Reported Outcomes


The purpose of the study is to assess self-reported side effects and neurocognitive (brain, mood and thinking) functioning among patients treated with commercial axi-cel therapy.


Aim 1: To evaluate longitudinal changes in neurocognition following axi-cel therapy Aim 2: Describe longitudinal changes in patient-reported outcomes for patients receiving axi-cel cell therapy.




Inclusion Criteria

Inclusion Criteria:

  • Diagnosed with diffuse large b-cell lymphoma, primary mediastinal b-cell lymphoma or transformed follicular lymphoma
  • Scheduled to receive commercial axi-cel at Moffitt Cancer Center
  • Able to speak and read standard english
  • Have no documented or observable psychiatric or neurological diagnoses that interfere with study participation (e.g., schizophrenia)
  • Have no history of traumatic brain injury, stroke, or dementia
  • Able to provide informed consent

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