Understanding and Predicting Breast Cancer Events after Treatment (UPBEAT)
This study is being done to see if patients receiving chemotherapy for breast cancer affects the heart, the ability to exercise and fatigue when compared to patients who do not have cancer.
Objective 1: To determine the incidence and time course of alterations in LV and aortic function, exercise capacity and fatigue in women treated for Stage I-III breast cancer. How are these changes interrelated, and how do they impact 7-year occurrence of CV events (myocardial infarction, cardiac death, and symptomatic HF) upon receipt of anthracycline or non-anthracycline-based chemotherapy? Objective 2: To determine which baseline demographic, behavioral, and psychosocial CV risk factors are associated with the development of LV/aortic dysfunction, impaired exercise capacity, symptomatic fatigue, disability, and CV events. Objective 3: To determine if Adj-C (with/without XRT) associated changes in serum biomarkers or other CV risk factors precede the onset of LV/aortic dysfunction, exercise intolerance, symptomatic fatigue, disability, or CV events.
Chemotherapy (NOS); Radiotherapy
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