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Bruce Wenig, MD

Department Chair, Pathology

Specialty: Pathology
Program: Pathology


Cancer Focus: Adrenal Carcinoma, Head and Neck Cancer, Oral Cavity or Throat Cancer, Thyroid Cancer

Dr. Bruce Wenig is a Senior Member in the Department of Anatomic Pathology at Moffitt Cancer Center. Dr. Wenig also serves as the Section Head of Anatomic Pathology External Network Consultation Services and the Section Head of Moffitt’s Head and Neck–Endocrine Pathology Program. Dr. Wenig received his MD from Sackler School of Medicine/New York State Division at the Tel Aviv University in Israel. He completed an Anatomic and Clinical Pathology Residency in the Department of Pathology at The Mount Sinai Medical Center, New York. Dr. Wenig completed a Fellowship in Surgical Pathology in the Department of Pathology and Laboratory Medicine at Cedars-Sinai Medical Center, Los Angeles, California, and a Fellowship in Otolaryngic Pathology at the Armed Forces Institute of Pathology in Washington, DC. Following his Fellowship, Dr. Wenig was a Staff Pathologist (1987-1998) for the Department of Otolaryngic-Endocrine Pathology at the Armed Forces Institute of Pathology, and also served as Chief, Division of Otolaryngic Pathology, Department of Endocrine and Otorhinolaryngic Head and Neck Pathology, Washington, DC. From 1998 to 2001, Dr. Wenig was the Vice Chairman for Anatomic Pathology and Professor of Pathology, Department of Pathology at Albert Einstein College of Medicine, Bronx, NY. From 2001 to 2003, he was Vice Chairman for Anatomic Pathology, Department of Pathology and Laboratory Medicine at Beth Israel Medical Center, St. Luke’s – Roosevelt Hospitals, New York, NY, and Associate Director, Continuum Cancer Center of New York. Prior to joining Moffitt, he was the Chairman, Department of Diagnostic Pathology and Laboratory Medicine, Mount Sinai Beth Israel, Mount Sinai St. Luke’s, Mount Sinai Roosevelt, New York; Vice Chairman of Anatomic Pathology, Department of Pathology, Mount Sinai Health System, NY; and Professor of Pathology, Department of Pathology, Icahn School of Medicine, Mount Sinai, NY. Dr. Wenig’s main clinical interests are in diseases of the head and neck and of endocrine organs including oncologic and non-neoplastic diseases. He has published extensively in peer-reviewed journals as well as authoring/editing several textbooks and numerous book chapters on head-and-neck and endocrine pathology. The third edition of his singly authored book, The Atlas of Head and Neck Pathology, was published in 2016. His research is primarily clinically focused, utilizing classic morphology in conjunction with immunohistochemical and molecular biologic techniques in the evaluation of a wide spectrum of diseases of the head and neck and of the endocrine organs. 

Education & Training


  • Cedars-Sinai Medical Center - Anatomic Pathology
  • Amred Forces Institute of Pathology - Otolaryngic Pathology


  • The Mount Sinai Medical Center - Anatomic Pathology

Medical School:

  • Sackler School of Medicine/NY Division at Tel Aviv University - MD
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  • Gale N, Cardesa A, Hernandez-Prera JC, Slootweg PJ, Wenig BM, Zidar N. Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems-A Short Review. Head Neck Pathol. 2020 Mar.14(4):1046-1051. Pubmedid: 32141027. Pmcid: PMC7669915.
  • Hernandez-Prera JC, Holmes BJ, Valentino A, Harshan M, Bacchi CE, Petersson F, Liu KK, Najfeld V, Wenig BM. Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck. Am J Surg Pathol. 2019 Nov.43(11):1483-1492. Pubmedid: 31464708.
  • Gupta R, Sandison A, Wenig BM, Thompson LDR. Data Set for the Reporting of Ear and Temporal Bone Tumors: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting. Arch Pathol Lab Med. 2019 May.143(5):593-602. Pubmedid: 30500288.
  • Turk A, Asa SL, Baloch ZW, Faquin WC, Fellegara G, Ghossein R, Giordano TJ, Livolsi V, Lloyd RV, Mete O, Rosai J, Suster S, Thompson LDR, Wenig BM. Interobserver Variability in the Histopathologic Assessment of Extrathyroidal Extension of Well Differentiated Thyroid Carcinoma Supports the New American Joint Committee on Cancer Eighth Edition Criteria for Tumor Staging. Thyroid. 2019 May.29(5):619-624. Pubmedid: 30913992.
  • Martin-Gomez L, Giuliano AR, Fulp WJ, Caudell J, Echevarria M, Sirak B, Abrahamsen M, Isaacs-Soriano KA, Hernandez-Prera JC, Wenig BM, Vorwald K, McMullen CP, Wadsworth JT, Slebos RJ, Chung CH. Human Papillomavirus Genotype Detection in Oral Gargle Samples Among Men With Newly Diagnosed Oropharyngeal Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg. 2019 May.145(5):460-466. Pubmedid: 30920604. Pmcid: PMC6537790.
  • Martin-Gomez L, Fulp WJ, Schell MJ, Sirak B, Abrahamsen M, Isaacs-Soriano KA, Lorincz A, Wenig B, Chung CH, Caudell JJ, Giuliano AR. Oral gargle-tumor biopsy human papillomavirus (HPV) agreement and associated factors among oropharyngeal squamous cell carcinoma (OPSCC) cases. Oral Oncol. 2019 May.92:85-91. Pubmedid: 31010629. Pmcid: PMC6736648.
  • Holmes BJ, Wenig BM. Virus-associated carcinomas of the head & neck: Update from the 2017 WHO classification. Ann Diagn Pathol. 2019 Feb.38:29-42. Pubmedid: 30415111.
  • Turk AT, Wenig BM. Thyroid tumors with follicular architecture. Ann Diagn Pathol. 2019 Feb.38:51-58. Pubmedid: 30419427.
  • Shah AA, Jain D, Ababneh E, Agaimy A, Hoschar AP, Griffith CC, Magliocca KR, Wenig BM, Rooper LM, Bishop JA. SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. Head Neck Pathol. 2019 Aug.14(2):465-472. Pubmedid: 31468350. Pmcid: PMC7235142.
  • Franchi A, Bishop JA, Coleman H, Flucke U, Licitra LF, Pendás JLL, Stelow EB, Toner M, Weinreb I, Wenig BM, Thompson LDR. Data Set for the Reporting of Carcinomas of the Nasal Cavity and Paranasal Sinuses: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting. Arch Pathol Lab Med. 2019 Apr.143(4):424-431. Pubmedid: 30500298.
  • Thompson LDR, Magliocca KR, Andreasen S, Kiss K, Rooper L, Stelow E, Wenig BM, Bishop JA. CAIX and pax-8 Commonly Immunoreactive in Endolymphatic Sac Tumors: A Clinicopathologic Study of 26 Cases with Differential Considerations for Metastatic Renal Cell Carcinoma in von Hippel-Lindau Patients. Head Neck Pathol. 2018 Oct.13(3):355-363. Pubmedid: 30291511. Pmcid: PMC6684711.
  • Rowe ME, Ozbek U, Machado RA, Yue LE, Hernandez-Prera JC, Valentino A, Qazi M, Brandwein-Weber M, Liu X, Wenig BM, Urken ML. The Prevalence of Extranodal Extension in Papillary Thyroid Cancer Based on the Size of the Metastatic Node: Adverse Histologic Features Are Not Limited to Larger Lymph Nodes. Endocr Pathol. 2018 Mar.29(1):80-85. Pubmedid: 29396810.
  • Nikiforov YE, Baloch ZW, Hodak SP, Giordano TJ, Lloyd RV, Seethala RR, Wenig BM. Change in Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm With Papillarylike Nuclear Features. JAMA Oncol. 2018 Aug.4(8):1125-1126. Pubmedid: 29902314. Pmcid: PMC6584712.
  • Valderrabano P, Khazai L, Thompson ZJ, Leon ME, Otto KJ, Hallanger-Johnson JE, Wadsworth JT, Wenig BM, Chung CH, Centeno BA, McIver B. Cancer Risk Stratification of Indeterminate Thyroid Nodules: A Cytological Approach. Thyroid. 2017 Oct.27(10):1277-1284. Pubmedid: 28806881. Pmcid: PMC6112164.
  • Stelow EB, Wenig BM. Update From The 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Nasopharynx. Head Neck Pathol. 2017 Mar.11(1):16-22. Pubmedid: 28247232. Pmcid: PMC5340728.
  • Wenig BM. Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants. Mod Pathol. 2017 Jan.30(s1):S112-S118. Pubmedid: 28060368.
  • Hernandez-Prera J, Machado R, Asa SL, Baloch ZW, Faquin WC, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Nikiforov YE, Seethala R, Suster S, Thompson LDR, Turk A, Sadow PM, Urken ML, Wenig BM. Pathologic Reporting of Tall-Cell Variant of Papillary Thyroid Cancer: Have We Reached a Consensus?. Thyroid. 2017 Dec.27(12):1498-1504. Pubmedid: 29020884.
  • Du E, Wenig BM, Su HK, Rowe ME, Haser GC, Asa SL, Baloch Z, Faquin WC, Fellegara G, Giordano T, Ghossein R, LiVolsi VA, Lloyd R, Mete O, Ozbek U, Rosai J, Suster S, Thompson LD, Turk AT, Urken ML. Inter-Observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma. Thyroid. 2016 Jun.26(6):816-819. Pubmedid: 27089928.
  • Isayeva T, Xu J, Ragin C, Dai Q, Cooper T, Carroll W, Dayan D, Vered M, Wenig B, Rosenthal E, Grizzle W, Anderson J, Willey CD, Yang ES, Brandwein-Gensler M. The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampens tumor invasion-integrated analysis of expression and kinomics pathways. Mod Pathol. 2015 May.28(5):631-653. Pubmedid: 25523612.
  • Shah AA, Wenig BM, LeGallo RD, Mills SE, Stelow EB. Morphology in conjunction with immunohistochemistry is sufficient for the diagnosis of mammary analogue secretory carcinoma. Head Neck Pathol. 2015 Mar.9(1):85-95. Pubmedid: 25078757. Pmcid: PMC4382490.
  • Wenig BM. Pitfalls in the biopsy diagnosis of intraoral minor salivary gland neoplasms: diagnostic considerations and recommended approach. Adv Anat Pathol. 2015 Jul.22(4):280-281. Pubmedid: 26050267.
  • Wenig BM. Viral-related diseases of the head and neck. Semin Diagn Pathol. 2015 Jan.32(1):1-2. Pubmedid: 25804340.
  • Urken ML, Mechanick JI, Sarlin J, Scherl S, Wenig BM. Pathologic reporting of lymph node metastases in differentiated thyroid cancer: a call to action for the College of American Pathologists. Endocr Pathol. 2014 Sep.25(3):214-218. Pubmedid: 24292975.
  • Wenig BM. Recently described sinonasal tract lesions/neoplasms: considerations for the new world health organization book. Head Neck Pathol. 2014 Mar.8(1):33-41. Pubmedid: 24595422. Pmcid: PMC3950390.
  • Li Y, Bai S, Carroll W, Dayan D, Dort JC, Heller K, Jour G, Lau H, Penner C, Prystowsky M, Rosenthal E, Schlecht NF, Smith RV, Urken M, Vered M, Wang B, Wenig B, Negassa A, Brandwein-Gensler M. Validation of the risk model: high-risk classification and tumor pattern of invasion predict outcome for patients with low-stage oral cavity squamous cell carcinoma. Head Neck Pathol. 2013 Sep.7(3):211-223. Pubmedid: 23250819. Pmcid: PMC3738758.
  • Slova D, Paniz Mondolfi A, Moisini I, Levi G, Urken M, Zevallos J, Mansoor S, Khorsandi A, Bloch D, Vidhun R, Wenig B. Colonic-type adenocarcinoma of the base of the tongue: a case report of a rare neoplasm. Head Neck Pathol. 2012 Jun.6(2):250-254. Pubmedid: 21948243. Pmcid: PMC3370020.
  • Wenig BM. Intraoperative consultation (IOC) in mucosal lesions of the upper aerodigestive tract. Head Neck Pathol. 2008 Jun.2(2):131-144. Pubmedid: 20614335. Pmcid: PMC2807550.
  • Bisceglia M, D'Angelo VA, Wenig BM. Endolymphatic sac papillary tumor (Heffner tumor). Adv Anat Pathol. 2006 May.13(3):131-138. Pubmedid: 16778477.
  • Ejaz A, Wenig BM. Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol. 2005 May.12(3):134-143. Pubmedid: 15900114.
  • Wenig BM, Mafee MF, Ghosh L. Fibro-osseous, osseous, and cartilaginous lesions of the orbit and paraorbital region. Correlative clinicopathologic and radiographic features, including the diagnostic role of CT and MR imaging. Radiol Clin North Am. 1998 Nov.36(6):1241-59, xii. Pubmedid: 9884700.
  • Schafer DR, Thompson LD, Smith BC, Wenig BM. Primary ameloblastoma of the sinonasal tract: a clinicopathologic study of 24 cases. Cancer. 1998 Feb.82(4):667-674. Pubmedid: 9477098.
  • Moran CA, Albores-Saavedra J, Wenig BM, Mena H. Pigmented extraadrenal paragangliomas. A clinicopathologic and immunohistochemical study of five cases. Cancer. 1997 Jan.79(2):398-402. Pubmedid: 9010114.
  • Wenig BM, Albores-Saavedra J, Buetow PC, Heffess CS. Pancreatic mucinous cystic neoplasm with sarcomatous stroma: a report of three cases. Am J Surg Pathol. 1997 Jan.21(1):70-80. Pubmedid: 8990143.
  • Thompson LD, Wenig BM, Adair CF, Shmookler BM, Heffess CS. Primary smooth muscle tumors of the thyroid gland. Cancer. 1997 Feb.79(3):579-587. Pubmedid: 9028371.
  • Barnes L, Ferlito A, Wenig BM. Laryngeal paragangliomas. A review and report of a single case. J Laryngol Otol. 1997 Feb.111(2):197-198. Pubmedid: 9102453.
  • Chan JK, Suster S, Wenig BM, Tsang WY, Chan JB, Lau AL. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol. 1997 Feb.21(2):226-234. Pubmedid: 9042291.
  • Wenig BM, Thompson LD, Frankel SS, Burke AP, Abbondanzo SL, Sesterhenn I, Heffner DK. Lymphoid changes of the nasopharyngeal and palatine tonsils that are indicative of human immunodeficiency virus infection. A clinicopathologic study of 12 cases. Am J Surg Pathol. 1996 May.20(5):572-587. Pubmedid: 8619422.
  • Thompson LD, Wenig BM, Ellis GL. Oncocytomas of the submandibular gland. A series of 22 cases and a review of the literature. Cancer. 1996 Dec.78(11):2281-2287. Pubmedid: 8940996.
  • Frankel SS, Wenig BM, Burke AP, Mannan P, Thompson LD, Abbondanzo SL, Nelson AM, Pope M, Steinman RM. Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science. 1996 Apr.272(5258):115-117. Pubmedid: 8600520.
  • Hamed G, Heffess CS, Shmookler BM, Wenig BM. Amyloid goiter. A clinicopathologic study of 14 cases and review of the literature. Am J Clin Pathol. 1995 Sep.104(3):306-312. Pubmedid: 7677120.
  • Wenig BM, Vinh TN, Smirniotopoulos JG, Fowler CB, Houston GD, Heffner DK. Aggressive psammomatoid ossifying fibromas of the sinonasal region: a clinicopathologic study of a distinct group of fibro-osseous lesions. Cancer. 1995 Oct.76(7):1155-1165. Pubmedid: 8630892.
  • Wenig BM, Adair CF, Heffess CS. Primary mucoepidermoid carcinoma of the thyroid gland: a report of six cases and a review of the literature of a follicular epithelial-derived tumor. Hum Pathol. 1995 Oct.26(10):1099-1108. Pubmedid: 7557943.
  • Saltarelli MG, Fleming MV, Wenig BM, Gal AA, Mansour KA, Travis WD. Primary basaloid squamous cell carcinoma of the trachea. Am J Clin Pathol. 1995 Nov.104(5):594-598. Pubmedid: 7572822.
  • Wenig BM. Necrotizing sialometaplasia of the larynx. A report of two cases and a review of the literature. Am J Clin Pathol. 1995 May.103(5):609-613. Pubmedid: 7741108.
  • Abbondanzo SL, Wenig BM. Non-Hodgkin's lymphoma of the sinonasal tract. A clinicopathologic and immunophenotypic study of 120 cases. Cancer. 1995 Mar.75(6):1281-1291. Pubmedid: 7882278.
  • Wenig BM, Devaney K, Bisceglia M. Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm. Cancer. 1995 Dec.76(11):2217-2229. Pubmedid: 8635024.
  • Klimstra DS, Wenig BM, Adair CF, Heffess CS. Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol. 1995 Dec.19(12):1371-1389. Pubmedid: 7503360.
  • Gaertner EM, Davidson M, Wenig BM. The columnar cell variant of thyroid papillary carcinoma. Case report and discussion of an unusually aggressive thyroid papillary carcinoma. Am J Surg Pathol. 1995 Aug.19(8):940-947. Pubmedid: 7611541.
  • Wenig BM. Laryngeal mucosal malignant melanoma. A clinicopathologic, immunohistochemical, and ultrastructural study of four patients and a review of the literature. Cancer. 1995 Apr.75(7):1568-1577. Pubmedid: 8826912.
  • Wenig BM. Lipomas of the larynx and hypopharynx: a review of the literature with the addition of three new cases. J Laryngol Otol. 1995 Apr.109(4):353-357. Pubmedid: 7782700.
  • Wenig BM, Abbondanzo SL, Childers EL, Kapadia SB, Heffner DR. Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of the head and neck. Hum Pathol. 1993 May.24(5):483-492. Pubmedid: 8491488.
  • Wenig BL, Stenson KM, Wenig BM, Tracey D. Effects of plume produced by the Nd:YAG laser and electrocautery on the respiratory system. Lasers Surg Med. 1993 Jan.13(2):242-245. Pubmedid: 8464311.
  • Wenig BM. Neuroendocrine tumors of the larynx. Head Neck. 1992 Jul.14(4):332-334. Pubmedid: 1517086.
  • Kuruvilla A, Wenig BM, Humphrey DM, Heffner DK. Leiomyosarcoma of the sinonasal tract. A clinicopathologic study of nine cases. Arch Otolaryngol Head Neck Surg. 1990 Nov.116(11):1278-1286. Pubmedid: 2242259.
  • Wenig BM, Heffner DK, Oertel YC, Johnson FB. Teflonomas of the larynx and neck. Hum Pathol. 1990 Jun.21(6):617-623. Pubmedid: 2351391.
  • Wenig BM, Weiss SW, Gnepp DR. Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol. 1990 Feb.14(2):134-141. Pubmedid: 2301699.
  • Wenig BM, Harpaz N, DelBridge C. Polymorphous low-grade adenocarcinoma of seromucous glands of the nasopharynx. A report of a case and a discussion of the morphologic and immunohistochemical features. Am J Clin Pathol. 1989 Jul.92(1):104-109. Pubmedid: 2665471.
  • Wenig BM, Hyams VJ, Heffner DK. Moderately differentiated neuroendocrine carcinoma of the larynx. A clinicopathologic study of 54 cases. Cancer. 1988 Dec.62(12):2658-2676. Pubmedid: 3056608.

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