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Hao Xie, MD, PhD

Specialty: Hematology/Oncology
Program: Gastrointestinal Oncology


Cancer Focus: Anal Cancer, Appendiceal (Appendix) Cancer, Cholangiocarcinoma (Bile Duct Cancer), Colon Cancer, Colorectal Cancer, Esophageal Cancer, Gallbladder Cancer, Liver Cancer, Pancreatic Cancer, Rectal Cancer, Small Intestine Cancer, Stomach (Gastric) Cancer

Dr. Hao Xie is as an Assistant Member in the Department of Gastrointestinal Oncology. Dr. Xie’s clinical interests include gastrointestinal cancers and early therapeutics with a focus on the development of clinical trials in colorectal cancer. Dr. Xie is a physician scientist. In addition to his clinical training, he also received a PhD degree in synthetic organic chemistry at Princeton University. His research interests include organic chemistry and chemical biology with a focus on their translation into the discovery of novel drug candidates for advanced colorectal cancer.  

Education & Training


  • Mayo Clinic - Hematology/Oncology


  • Yale University School of Medicine - Internal Medicine

Medical School:

  • Cleveland Clinic Lerner College of Medicine - MD
Participating Trials

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.


  • Xie H, Kim RD. The Application of Circulating Tumor DNA in the Screening, Surveillance, and Treatment Monitoring of Colorectal Cancer. Ann Surg Oncol. 2021 Mar.28(3):1845-1858. Pubmedid: 32776184.
  • Chakrabarti S, Xie H, Urrutia R, Mahipal A. The Promise of Circulating Tumor DNA (ctDNA) in the Management of Early-Stage Colon Cancer: A Critical Review. Cancers (Basel). 2020 Sep.12(10). Pubmedid: 33003583. Pmcid: PMC7601010.
  • Yin F, Xie H, Lai J, Chen Y, Dong J, Zhang X, Liu X. Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer. Anticancer Res. 2020 Oct.40(10):5411-5416. Pubmedid: 32988861.
  • Yin F, Saad M, Xie H, Lin J, Jackson CR, Ren B, Lawson C, Karamchandani DM, Bernabeu BQ, Jiang W, Dhir T, Zheng R, Schultz CW, Zhang D, Thomas CL, Zhang X, Lai J, Schild M, Zhang X, Liu X. Validation of American Joint Committee on Cancer 8th edition of TNM staging in resected distal pancreatic cancer. World J Gastrointest Pharmacol Ther. 2020 Jun.11(2):25-39. Pubmedid: 32550043. Pmcid: PMC7288727.
  • Boland JM, Kroneman TN, Jenkins SM, Terra SBSP, Xie H, Molina J, Mounajjed T, Roden AC. Ki-67 Labeling Index in Pulmonary Carcinoid Tumors: Comparison Between Small Biopsy and Resection Using Tumor Tracing and Hot Spot Methods. Arch Pathol Lab Med. 2020 Jan. Pubmedid: 31944862.
  • Xie H, Kim RD. ASO Author Reflections: Clinical Utility of Circulating Tumor DNA Analysis in Colorectal Cancer: Current Status. Ann Surg Oncol. 2020 Aug.27(Suppl 3):890. Pubmedid: 32812106.
  • Xie H, Boland JM, Maleszewski JJ, Aubry MC, Yi ES, Jenkins SM, Koepplin JW, Terra SBSP, Mansfield AS, Roden AC. Expression of delta-like protein 3 is reproducibly present in a subset of small cell lung carcinomas and pulmonary carcinoid tumors. Lung Cancer. 2019 Sep.135:73-79. Pubmedid: 31447005.
  • Ogden JJ, Xie H, Marks RS, Leventakos K. Two Cases of Krukenberg Tumors from ALK-Rearranged Lung Adenocarcinoma: An Uncommon Site of Metastasis. J Thorac Oncol. 2019 Oct.14(10):e229-e230. Pubmedid: 31558235.
  • Xie H, Liu J, Yadav S, Keutgen X, Hobday T, Strosberg JR, Halfdanarson T. The Role of Perioperative Systemic Therapy in Localized Pancreatic Neuroendocrine Neoplasms. Neuroendocrinology. 2019 May.110(3-4):234-245. Pubmedid: 31121586.
  • Xie H, Adjei AA. Antibody-Drug Conjugates for the Therapy of Thoracic Malignancies. J Thorac Oncol. 2019 Mar.14(3):358-376. Pubmedid: 30599202.
  • Ma WW, Xie H, Fetterly G, Pitzonka L, Whitworth A, LeVea C, Wilton J, Mantione K, Schihl S, Dy GK, Boland P, Iyer R, Tan W, Brady W, Straubinger RM, Adjei AA. A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib With Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients. Am J Clin Oncol. 2019 Feb.42(2):184-189. Pubmedid: 30418178. Pmcid: PMC6345595.
  • Allende DS, Pai RK, Xie H, Liu X. Colorectal Serrated Polyp With Stromal Changes: An Interobserver Agreement Study. Gastroenterology Res. 2019 Dec.12(6):299-304. Pubmedid: 31803309. Pmcid: PMC6879030.
  • Terra SBSP, Xie H, Boland JM, Mansfield AS, Molina JR, Roden AC. Loss of ATRX expression predicts worse prognosis in pulmonary carcinoid tumors. Hum Pathol. 2019 Dec.94:78-85. Pubmedid: 31499081.
  • Yadav S, Xie H, Bin-Riaz I, Sharma P, Durani U, Goyal G, Borah B, Borad MJ, Smoot RL, Roberts LR, Go RS, McWilliams RR, Mahipal A. Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis. Eur J Surg Oncol. 2019 Aug.45(8):1432-1438. Pubmedid: 30914290.
  • Xie H, Paradise BD, Ma WW, Fernandez-Zapico ME. Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer. Cells. 2019 Apr.8(5). Pubmedid: 31035664. Pmcid: PMC6562674.
  • Jin Z, Zhang D, Zhang Q, Lai J, Akki A, Esnakula A, Kresak J, Gonzalo DH, Draganov PV, Xie H, Liu X. Desmoplasia and Detached Papillae in Early Esophageal Adenocarcinoma: A Histologic Study on Endoscopic Submucosal Dissection Specimens. Gastroenterology Res. 2019 Apr.12(2):72-77. Pubmedid: 31019616. Pmcid: PMC6469900.
  • Ogden JR, Xie H, Ma WW, Hubbard JM. The Management of Older Adults with Pancreatic Adenocarcinoma. Geriatrics (Basel). 2018 Nov.3(4). Pubmedid: 31011120. Pmcid: PMC6371178.
  • Wu XR, Liu HS, Shi XY, Zhou WX, Jiang ZN, Huang Y, Karamchandani DM, Goldblum JR, Xiao SY, Zhu HF, Feely MM, Collinsworth AL, Esnakula A, Xie H, Shen B, Lan P, Liu XL. Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists. Gastroenterol Res Pract. 2018 Apr.2018:8715263. Pubmedid: 29849600. Pmcid: PMC5937390.
  • Horvath B, Allende D, Xie H, Guirguis J, Jeung J, Lapinski J, Patil D, McCullough AJ, Dasarathy S, Liu X. Interobserver Variability in Scoring Liver Biopsies with a Diagnosis of Alcoholic Hepatitis. Alcohol Clin Exp Res. 2017 Sep.41(9):1568-1573. Pubmedid: 28654190. Pmcid: PMC6309429.
  • Roma AA, Park KJ, Xie H, De Vivar AD, Alvarado-Cabrero I, Rutgers JKL, Barbuto D, Silva EG. Role of Lymphovascular Invasion in Pattern C Invasive Endocervical Adenocarcinoma. Am J Surg Pathol. 2017 Sep.41(9):1205-1211. Pubmedid: 28614201.
  • Horvath B, Zhu L, Allende D, Xie H, Guirguis J, Cruise M, Patil DT, O'Shea R, Rivas J, Yordanka R, Lan N, Liu X. Histology and Glutamine Synthetase Immunoreactivity in Liver Biopsies From Patients With Congestive Heart Failure. Gastroenterology Res. 2017 Jun.10(3):182-189. Pubmedid: 28725306. Pmcid: PMC5505284.
  • Roma AA, Liu X, Patil DT, Xie H, Allende D. Proposed Terminology for Anal Squamous Lesions: Its Application and Interobserver Agreement Among Pathologists in Academic and Community Hospitals. Am J Clin Pathol. 2017 Jul.148(1):81-90. Pubmedid: 28605400.
  • Xie H, Adjei AA. Avelumab: another active immune checkpoint inhibitor in non-small cell lung cancer. Transl Lung Cancer Res. 2017 Dec.6(Suppl 1):S41-S43. Pubmedid: 29299408. Pmcid: PMC5750158.
  • Sun X, Yuan L, Li Y, Shen B, Xie H, Liu X. Association of granulomas in mesenteric lymph nodes in Crohn's disease with younger age and transmural inflammation. J Gastroenterol Hepatol. 2017 Aug.32(8):1463-1468. Pubmedid: 28087973.
  • Horvath B, Singh P, Xie H, Thota PN, Sun X, Liu X. Expression of p53 predicts risk of prevalent and incident advanced neoplasia in patients with Barrett's esophagus and epithelial changes indefinite for dysplasia. Gastroenterol Rep (Oxf). 2016 Nov.4(4):304-309. Pubmedid: 26486567. Pmcid: PMC5193059.
  • Liu G, Lin J, Xie H, Shen B, Stocchi L, Liu X. Histomorphological features and prognosis of colitis-associated colorectal cancer in patients with primary sclerosing cholangitis. Scand J Gastroenterol. 2016 May.50(11):1389-1396. Pubmedid: 26061393.
  • Murphy ES, Xie H, Merchant TE, Yu JS, Chao ST, Suh JH. Review of cranial radiotherapy-induced vasculopathy. J Neurooncol. 2015 May.122(3):421-429. Pubmedid: 25670390.
  • Ahluwalia MS, Xie H, Dahiya S, Hashemi-Sadraei N, Schiff D, Fisher PG, Chamberlain MC, Pannullo S, Newton HB, Brewer C, Wood L, Prayson R, Elson P, Peereboom DM. Efficacy and patient-reported outcomes with dose-intense temozolomide in patients with newly diagnosed pure and mixed anaplastic oligodendroglioma: a phase II multicenter study. J Neurooncol. 2015 Mar.122(1):111-119. Pubmedid: 25534576.
  • Sadraei NH, Dahiya S, Chao ST, Murphy ES, Osei-Boateng K, Xie H, Suh JH, Peereboom DM, Stevens GH, Ahluwalia MS. Treatment of cerebral radiation necrosis with bevacizumab: the Cleveland clinic experience. Am J Clin Oncol. 2015 Jun.38(3):304-310. Pubmedid: 23799286.
  • Xie H, Tubbs R, Yang B. Detection of MGMT promoter methylation in glioblastoma using pyrosequencing. Int J Clin Exp Pathol. 2015 Feb.8(2):1790-1796. Pubmedid: 25973069. Pmcid: PMC4396208.
  • Lai KK, Horvath B, Xie H, Wu X, Lewis BL, Pai RK, Plesec T, Patil DT, Gordon IO, Wang Y, Shen B, Goldblum JR, Liu X. Risk for colorectal neoplasia in patients with inflammatory bowel disease and mucosa indefinite for dysplasia. Inflamm Bowel Dis. 2015 Feb.21(2):378-384. Pubmedid: 25569733.
  • Li ZG, Zhu H, Shi H, Xie H, Goldblum JR, Thota PN, Liu X. Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction. J Dig Dis. 2015 Apr.16(4):197-204. Pubmedid: 25620066.
  • Xie H, Ahluwalia MS, Peereboom DM. The Cleveland Clinic experience with primary central nervous system lymphoma. Am J Clin Oncol. 2015 Apr.38(2):140-146. Pubmedid: 23608829.
  • Xie H, Xiao SY, Pai R, Jiang W, Shadrach B, Carver P, Wang Y, Shen B, Zhou W, Liu X. Diagnostic utility of TP53 and cytokeratin 7 immunohistochemistry in idiopathic inflammatory bowel disease-associated neoplasia. Mod Pathol. 2014 Feb.27(2):303-313. Pubmedid: 23887291.
  • Lewis B, Lin J, Wu X, Xie H, Shen B, Lai K, Manilich E, Liu X. Crohn's disease-like reaction predicts favorable prognosis in colitis-associated colorectal cancer. Inflamm Bowel Dis. 2013 Sep.19(10):2190-2198. Pubmedid: 23917251.
  • Xie H, Jiang W, Jiang J, Wang Y, Kim R, Liu X, Liu X. Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma. Cancer. 2013 Jan.119(1):173-181. Pubmedid: 22736490.
  • Xie H, Jiang W, Xiao SY, Liu X. High expression of survivin is prognostic of shorter survival but not predictive of adjuvant gemcitabine benefit in patients with resected pancreatic adenocarcinoma. J Histochem Cytochem. 2013 Feb.61(2):148-155. Pubmedid: 23124118. Pmcid: PMC3636689.
  • Xie H, Dahiya S, Murphy ES, Chao ST, Suh JH, Stevens GH, Peereboom DM, Ahluwalia MS. Primary central nervous system lymphoma in the elderly: the Cleveland clinic experience. Anticancer Res. 2013 Aug.33(8):3251-3258. Pubmedid: 23898087.
  • Liu X, Melton GB, Xie H, Dietz DW. Extramammary Paget disease in peristomal skin: report of a unique case. J Gastrointest Surg. 2012 Oct.16(10):1967-1971. Pubmedid: 22547349.
  • Xie H, Lin J, Thomas DG, Jiang W, Liu X. Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma. Int J Clin Exp Pathol. 2012 Oct.5(4):347-355. Pubmedid: 22670179. Pmcid: PMC3365819.
  • Xie H, Peereboom DM. Ogilvie's syndrome during chemotherapy with high-dose methotrexate for primary CNS lymphoma. J Clin Oncol. 2012 Jul.30(21):e192-e194. Pubmedid: 22711852.
  • Xie H, Sammis GM, Flamme EM, Kraml CM, Sorensen EJ. The catalytic asymmetric Diels-Alder reactions and post-cycloaddition reductive transpositions of 1-hydrazinodienes. Chemistry. 2011 Sep.17(40):11131-11134. Pubmedid: 21898626. Pmcid: PMC3222330.
  • Sammis GM, Flamme EM, Xie H, Ho DM, Sorensen EJ. Design, synthesis, and reactivity of 1-hydrazinodienes for use in organic synthesis. J Am Chem Soc. 2005 Jun.127(24):8612-8613. Pubmedid: 15954764.

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