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Juan Hernandez Prera, MD

Specialty: Pathology
Program: Pathology


Cancer Focus: Adrenal Carcinoma, Head and Neck Cancer, Oral Cavity or Throat Cancer, Thyroid Cancer

Dr. Juan Carlos Hernandez-Prera is an Assistant Member in Anatomic Pathology at Moffitt Cancer Center. Dr. Hernandez-Prera received his MD from Universidad Francisco Marroquín, Guatemala. He completed an Anatomic Pathology Residency and a Fellowship in Head and Neck and Endocrine Pathology in the Department of Pathology at The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York. Dr. Hernandez-Prera most recently was an Assistant Professor at Icahn School of Medicine at Mount Sinai and Attending Pathologist at Mount Sinai Beth Israel, New York. Dr. Hernandez-Prera is a board-certified anatomic pathologist with expertise in the subspecialty of Head and Neck/Endocrine Pathology. His research focus is analysis of the clinical, pathological, immunohistochemical, molecular and cytogenetic features of Head and Neck/Endocrine tumors. He is interested in identifying novel biomarkers that will help guide translation into new diagnostic, therapeutic and prognostic tools. He aims to bridge classical histomorphology with molecular advances to better characterize Head and Neck/Endocrine tumors.

Education & Training


  • Mount Sinai Hospital Icahn School of Medicine - Head & Neck and Endocrine Pathology


  • Mount Sinai Hospital Icahn School of Medicine - Pathology

Medical School:

  • Universidad Francisco Marroquin - MD
Participating Trials

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  • Gale N, Cardesa A, Hernandez-Prera JC, Slootweg PJ, Wenig BM, Zidar N. Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems-A Short Review. Head Neck Pathol. 2020 Mar.14(4):1046-1051. Pubmedid: 32141027. Pmcid: PMC7669915.
  • Hernandez-Prera JC. The evolving concept of aggressive histological variants of differentiated thyroid cancer. Semin Diagn Pathol. 2020 Mar.37(5):228-233. Pubmedid: 32241577.
  • Rodrigo JP, Hernandez-Prera JC, Randolph GW, Zafereo ME, Hartl DM, Silver CE, Suárez C, Owen RP, Bradford CR, Mäkitie AA, Shaha AR, Bishop JA, Rinaldo A, Ferlito A. Parathyroid cancer: An update. Cancer Treat Rev. 2020 Mar.86:102012. Pubmedid: 32247225.
  • Chaudhary R, Wang X, Cao B, De La Iglesia J, Masannat J, Song F, Hernandez-Prera JC, Gimbrone NT, Slebos RJ, Chung CH. Long noncoding RNA, LINC00460, as a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC). Am J Transl Res. 2020 Feb.12(2):684-696. Pubmedid: 32194915. Pmcid: PMC7061833.
  • Strosberg C, Ferlito A, Triantafyllou A, Gnepp DR, Bishop JA, Hellquist H, Strojan P, Willems SM, Stenman G, Rinaldo A, Hernandez-Prera JC. Update on Neuroendocrine Carcinomas of the Larynx. Am J Clin Pathol. 2019 Nov.152(6):686-700. Pubmedid: 31415081.
  • Hernandez-Prera JC, Holmes BJ, Valentino A, Harshan M, Bacchi CE, Petersson F, Liu KK, Najfeld V, Wenig BM. Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck. Am J Surg Pathol. 2019 Nov.43(11):1483-1492. Pubmedid: 31464708.
  • Martin-Gomez L, Giuliano AR, Fulp WJ, Caudell J, Echevarria M, Sirak B, Abrahamsen M, Isaacs-Soriano KA, Hernandez-Prera JC, Wenig BM, Vorwald K, McMullen CP, Wadsworth JT, Slebos RJ, Chung CH. Human Papillomavirus Genotype Detection in Oral Gargle Samples Among Men With Newly Diagnosed Oropharyngeal Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg. 2019 May.145(5):460-466. Pubmedid: 30920604. Pmcid: PMC6537790.
  • Prajapati S, Hernandez-Prera JC. Putting All the Pieces Together: Clinical, Macroscopic and Microscopic Characteristics of Subacute Thyroiditis. Head Neck Pathol. 2019 Jun.13(2):231-234. Pubmedid: 29427032. Pmcid: PMC6514204.
  • McMullen C, Chung CH, Hernandez-Prera JC. Evolving role of human papillomavirus as a clinically significant biomarker in head and neck squamous cell carcinoma. Expert Rev Mol Diagn. 2019 Jan.19(1):63-70. Pubmedid: 30575409.
  • Moubayed SP, Machado R, Tuttle RM, Orloff LA, Randolph G, Hernandez-Prera JC, Griffin MJ, Urken ML. Enhanced interdisciplinary communication: development of an interactive thyroid nodule/cancer disease map. Laryngoscope. 2019 Jan.129(1):269-274. Pubmedid: 30194697.
  • Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A. Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. Adv Ther. 2019 Aug.36(8):1950-1974. Pubmedid: 31209701. Pmcid: PMC6822986.
  • Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A. Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis. Cancer Treat Rev. 2019 Aug.78:42-51. Pubmedid: 31437725.
  • Hernandez-Prera JC. Historical Evolution of the Polymorphous Adenocarcinoma. Head Neck Pathol. 2018 Sep.13(3):415-422. Pubmedid: 30187348. Pmcid: PMC6684715.
  • Rowe ME, Ozbek U, Machado RA, Yue LE, Hernandez-Prera JC, Valentino A, Qazi M, Brandwein-Weber M, Liu X, Wenig BM, Urken ML. The Prevalence of Extranodal Extension in Papillary Thyroid Cancer Based on the Size of the Metastatic Node: Adverse Histologic Features Are Not Limited to Larger Lymph Nodes. Endocr Pathol. 2018 Mar.29(1):80-85. Pubmedid: 29396810.
  • Moubayed SP, Machado R, Osorio M, Khorsandi A, Hernandez-Prera J, Urken ML. Metastatic squamous cell carcinoma to the superior cervical ganglion mimicking a retropharyngeal lymph node. Am J Otolaryngol. 2018 Jul.38(6):720-723. Pubmedid: 28844495.
  • Hernandez-Prera JC, Kwan R, Tripodi J, Chiosea S, Cordon-Cardo C, Najfeld V, Demicco EG. Reappraising hyalinizing clear cell carcinoma: A population-based study with molecular confirmation. Head Neck. 2017 Mar.39(3):503-511. Pubmedid: 27898192.
  • Machado RA, Moubayed SP, Khorsandi A, Hernandez-Prera JC, Urken ML. Intermittent facial spasms as the presenting sign of a recurrent pleomorphic adenoma. World J Clin Oncol. 2017 Feb.8(1):86-90. Pubmedid: 28246588. Pmcid: PMC5309717.
  • Hernandez-Prera J, Machado R, Asa SL, Baloch ZW, Faquin WC, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Nikiforov YE, Seethala R, Suster S, Thompson LDR, Turk A, Sadow PM, Urken ML, Wenig BM. Pathologic Reporting of Tall-Cell Variant of Papillary Thyroid Cancer: Have We Reached a Consensus?. Thyroid. 2017 Dec.27(12):1498-1504. Pubmedid: 29020884.
  • Prabhu AV, Sturgis CD, Lai C, Maxwell JH, Merzianu M, Hernandez-Prera JC, Purgina B, Thompson LDR, Tuluc M, Yang X, Seethala RR, Ferris RL, Chiosea SI. Improving margin revision: Characterization of tumor bed margins in early oral tongue cancer. Oral Oncol. 2017 Dec.75:184-188. Pubmedid: 29074194. Pmcid: PMC5774620.
  • Osorio M, Moubayed SP, Hernandez-Prera J, Scott JC, Urken ML. Primary mucosal melanoma of the palatine tonsil: Report of a case and review of the literature. Am J Otolaryngol. 2017 Apr.38(4):501-504. Pubmedid: 28449824.
  • Govindaraj S, Iloreta AM, Tong CC, Hernandez-Prera JC. Evaluation of Patients with Sinonasal and Ventral Skull Base Malignancies. Otolaryng Clin N Am. 2017 Apr.50(2):221-244. Pubmedid: 28314398.
  • Likhterov I, Osorio M, Moubayed SP, Hernandez-Prera JC, Rhodes R, Urken ML. The Ethical Implications of the Reclassification of Noninvasive Follicular Variant Papillary Thyroid Carcinoma. Thyroid. 2016 Sep.26(9):1167-1172. Pubmedid: 27480127.
  • Madrigal E, Prajapati S, Hernandez-Prera JC. Introducing a Virtual Reality Experience in Anatomic Pathology Education. Am J Clin Pathol. 2016 Oct.146(4):462-468. Pubmedid: 27594429.
  • Capo JA, Moubayed D, Moubayed SP, Hernandez-Prera JC, Khorsandi A, Buchbinder D, Urken ML. Pediatric Myofibroma of the Palate with Ulceration and Bone Destruction. Case Rep Otolaryngol. 2016 May.2016:1432764. Pubmedid: 27403363. Pmcid: PMC4923519.
  • Haser GC, Su HK, Hernandez-Prera JC, Khorsandi AS, Wang BY, Urken ML. Pediatric odontogenic fibromyxoma of the mandible: Case report and review of the literature. Head Neck. 2016 Jan.38(1):E25-E28. Pubmedid: 25898806.
  • Saini AT, Hernandez-Prera JC, Teng MS. Pyriform sinus soft-tissue mass recurring in esophagus after excision. JAMA Otolaryngol Head Neck Surg. 2015 Jun.141(6):573-574. Pubmedid: 25856625.
  • Castain C, Sempoux C, Brunt EM, Causse O, Heitzmann A, Hernandez-Prera JC, Le Bail B, Schirmacher P, Thung SN, Balabaud C, Bioulac-Sage P. Coexistence of inflammatory hepatocellular adenomas with HNF1α-inactivated adenomas: is there an association?. Histopathology. 2014 May.64(6):890-895. Pubmedid: 24236804.
  • Hernandez-Prera JC, Polydorides AD. Colitis cystica profunda indefinite for dysplasia in Crohn disease: a potential diagnostic pitfall. Pathol Res Pract. 2014 Dec.210(12):1075-1078. Pubmedid: 25307411.
  • Chang CY, Hernandez-Prera JC, Roayaie S, Schwartz M, Thung SN. Changing epidemiology of hepatocellular adenoma in the United States: review of the literature. Int J Hepatol. 2013 Jan.2013:604860. Pubmedid: 23509632. Pmcid: PMC3595661.
  • Balabaud C, Al-Rabih WR, Chen PJ, Evason K, Ferrell L, Hernandez-Prera JC, Huang SF, Longerich T, Park YN, Quaglia A, Schirmacher P, Sempoux C, Thung SN, Torbenson M, Wee A, Yeh MM, Yeh SH, Le Bail B, Zucman-Rossi J, Bioulac-Sage P. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. Int J Hepatol. 2013 Apr.2013:268625. Pubmedid: 23691331. Pmcid: PMC3654480.
  • Ko HM, Hernandez-Prera JC, Zhu H, Dikman SH, Sidhu HK, Ward SC, Thung SN. Morphologic features of extrahepatic manifestations of hepatitis C virus infection. Clin Dev Immunol. 2012 Jun.2012:740138. Pubmedid: 22919404. Pmcid: PMC3420144.
  • Hernandez-Prera JC, Polydorides AD. Anisakidosis of the sigmoid colon disguising as metastatic carcinoma: a case report and review of the literature. Pathol Res Pract. 2012 Jul.208(7):433-435. Pubmedid: 22658479.
  • Weissferdt A, Hernandez JC, Kalhor N, Moran CA. Spindle cell thymomas: an immunohistochemical study of 30 cases. Appl Immunohistochem Mol Morphol. 2011 Jul.19(4):329-335. Pubmedid: 21386704.
  • Barnoya J, Arvizu M, Jones MR, Hernandez JC, Breysse PN, Navas-Acien A. Secondhand smoke exposure in bars and restaurants in Guatemala City: before and after smoking ban evaluation. Cancer Causes Control. 2011 Jan.22(1):151-156. Pubmedid: 21046446.

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