ER Stress Thwarts Protective Anti-Tumor Immunity Through T-bet Repression

Inhibiting Chop

Research results reveal a new role of Chop as an intrinsic mediator of T cell dysfunction in tumors and suggest the therapeutic potential of inhibiting Chop or the UPR mediator Perk in CD8+ T cells as a platform to overcome tumor-induced T cell suppression and a strategy to boost the efficacy of T cell-based immunotherapies. Read more