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Srikumar Chellappan, PhD

Chair, Department of Tumor Biology

Department Chair: Tumor Biology,

Program: Tumor Biology

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We focus on regulatory pathways that promote tumor growth, angiogenesis and metastasis and how they can be targeted for drug discovery.


    • Tumor Biology
    • Thoracic Oncology
    • Melanoma Research Center of Excellence
    • Lung Cancer Center of Excellence
    • Cancer Biology and Evolution Program
    • Cancer Biology and Evolution Program

Education & Training


  • Duke University Medical Center, Postdoctoral Fellowship - Molecular Biology

The major research interest is to understand the mechanisms by which extra-cellular signals regulate the cell cycle machinery and how a loss of this regulation leads to oncogenesis. We focus on how the retinoblastoma protein and its downstream target E2F transcription factor mediate proliferation, differentiation and apoptosis in response to specific signaling cascades. In this context, we have observed that the signaling molecule Raf-1 can physically interact with the Rb protein in response to proliferative signals and inactivate it independent of cyclins and cyclin dependent kinases. Disruption of the Rb-Raf-1 interactions by a small peptide inhibits cell proliferation as well as VEGF-induced angiogenic process. Attempts are being made to identify potential drugs that can mimic this peptide. Our studies have also shown that JNK1 and p38 kinases can modulate Rb and E2F activity in opposite fashions. The potential role of these events in apoptosis is being evaluated. Our lab is also studying the role of prohibitin, a potential tumor suppressor protein that interacts with Rb and represses E2F transcriptional activity. Mutations of the prohibitin gene have been reported in breast cancer and we find that prohibitin can inhibit certain apoptotic pathways. Efforts are being made to understand the specific mechanism by which prohibitin regulates cell proliferation and apoptosis. A recent avenue of research has been on the role of nicotinic receptor signaling in lung cancer, especially how exposure to nicotine promotes the growth and progression of tumors and renders them resistant to death induced by chemotherapeutic drugs. We believe our studies will identify molecular targets for developing novel chemotherapeutic agents. Key words: Rb, Raf-1, E2F, Cell cycle, prohibitin, nicotine, lung cancer, ASK1, p38, angiogenesis.


  • Maan M, Agrawal NJ, Padmanabhan J, Leitzinger CC, Rivera-Rivera Y, Saavedra HI, Chellappan SP. Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells. Biochim Biophys Acta Mol Cell Res. 2021 Mar.1868(3):118929. Pubmedid: 33310066. Pmcid: PMC8054712.
  • Padmanabhan J, Saha B, Powell C, Mo Q, Perez BA, Chellappan S. Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells. Cancers (Basel). 2021 Aug.13(15). Pubmedid: 34359807. Pmcid: PMC8345430.
  • Rivera-Rivera Y, Marina M, Jusino S, Lee M, Velázquez JV, Chardón-Colón C, Vargas G, Padmanabhan J, Chellappan SP, Saavedra HI. The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Sci Rep. 2021 Apr.11(1):9016. Pubmedid: 33907253. Pmcid: PMC8079711.
  • Bora-Singhal N, Mohankumar D, Saha B, Colin CM, Lee JY, Martin MW, Zheng X, Coppola D, Chellappan S. Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Sci Rep. 2020 Mar.10(1):4722. Pubmedid: 32170113. Pmcid: PMC7069992.
  • Faião-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KSM. HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma. Clin Cancer Res. 2019 Sep.25(18):5686-5701. Pubmedid: 31227503. Pmcid: PMC6744978.
  • Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S. Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Cell Rep. 2019 Sep.28(11):2824-2836.e8. Pubmedid: 31509745. Pmcid: PMC6759858.
  • Alhothali M, Mathew M, Iyer G, Lawrence HR, Yang S, Chellappan S, Padmanabhan J. Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC. Int J Mol Sci. 2019 May.20(10). Pubmedid: 31100813. Pmcid: PMC6567171.
  • Andey T, Bora-Singhal N, Chellappan S, Singh M. Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors. Nanomedicine. 2019 Jun.18:31-43. Pubmedid: 30831275. Pmcid: PMC7787332.
  • Sikder S, Kumari S, Kumar M, Sen S, Singhal NB, Chellappan S, Godbole M, Chandrani P, Dutt A, Gopinath KS, Kundu TK. Chromatin protein PC4 is downregulated in breast cancer to promote disease progression: Implications of miR-29a. Oncotarget. 2019 Dec.10(64):6855-6869. Pubmedid: 31839879. Pmcid: PMC6901337.
  • Schaal CM, Bora-Singhal N, Kumar DM, Chellappan SP. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer. Mol Cancer. 2018 Oct.17(1):149. Pubmedid: 30322398. Pmcid: PMC6190543.
  • Kothari N, Teer JK, Abbott AM, Srikumar T, Zhang Y, Yoder SJ, Brohl AS, Kim RD, Reed DR, Shibata D. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Cancer. 2016 Sep.122(18):2828-2835. Pubmedid: 27244218. Pmcid: PMC5014625.
  • Schaal C, Chellappan S. Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. PLoS One. 2016 May.11(5):e0156451. Pubmedid: 27228072. Pmcid: PMC4882068.
  • Woods N, Trevino J, Coppola D, Chellappan S, Yang S, Padmanabhan J. Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling. Oncotarget. 2015 Nov.6(34):35931-35948. Pubmedid: 26440150. Pmcid: PMC4742152.
  • Chellappan SP, Pillai S, Trevino JG, Rawal B, Singh S, Kovacs M, Li X, Schell MJ, Haura EB, Bepler G. β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. Cancer Res. 2015 Mar.75(6):1009-1020. Pubmedid: 25600647. Pmcid: PMC4359962.
  • Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells. Stem Cells. 2015 Jun.33(6):1705-1718. Pubmedid: 25754111. Pmcid: PMC4441573.
  • Schaal C, Padmanabhan J, Chellappan S. The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression. Cancers (Basel). 2015 Jul.7(3):1447-1471. Pubmedid: 26264026. Pmcid: PMC4586778.
  • Bora-Singhal N, Perumal D, Nguyen J, Chellappan S. Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer. Neoplasia. 2015 Jul.17(7):538-551. Pubmedid: 26297432. Pmcid: PMC4547412.
  • Pillai S, Chellappan SP. ChIP on chip and ChIP-Seq assays: genome-wide analysis of transcription factor binding and histone modifications. Methods Mol Biol. 2015 Dec.1288:447-472. Pubmedid: 25827896.
  • Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun. 2015 Dec.6:10072. Pubmedid: 26656453. Pmcid: PMC4682058.
  • Pillai S, Dasgupta P, Chellappan SP. Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. Methods Mol Biol. 2015 Aug.1288:429-446. Pubmedid: 25827895.
  • Rizwani W, Chellappan SP. In vitro replication assay with Mammalian cell extracts. Methods Mol Biol. 2015 Apr.1288:349-362. Pubmedid: 25827890.
  • Singh S, Chellappan S. Lung cancer stem cells: Molecular features and therapeutic targets. Mol Aspects Med. 2014 Oct.39:50-60. Pubmedid: 24016594. Pmcid: PMC3949216.
  • Perumal D, Pillai S, Nguyen J, Schaal C, Coppola D, Chellappan SP. Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC. Oncotarget. 2014 Nov.5(21):10486-10502. Pubmedid: 25401222. Pmcid: PMC4279388.
  • Andey T, Marepally S, Patel A, Jackson T, Sarkar S, O'Connell M, Reddy RC, Chellappan S, Singh P, Singh M. Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model. J Control Release. 2014 Jun.184:67-78. Pubmedid: 24727000. Pmcid: PMC4674431.
  • Rizwani W, Schaal C, Kunigal S, Coppola D, Chellappan S. Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells. PLoS One. 2014 Jul.9(7):e100888. Pubmedid: 25029110. Pmcid: PMC4100745.
  • Nair S, Bora-Singhal N, Perumal D, Chellappan S. Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner. Mol Cancer. 2014 Jul.13:173. Pubmedid: 25028095. Pmcid: PMC4121302.
  • Schaal C, Chellappan SP. Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res. 2014 Jan.12(1):14-23. Pubmedid: 24398389. Pmcid: PMC3915512.
  • Schaal C, Pillai S, Chellappan SP. The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis. Adv Cancer Res. 2014 Dec.121:147-182. Pubmedid: 24889531.
  • Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ. IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene. 2013 Jan.32(2):151-159. Pubmedid: 22330135. Pmcid: PMC4109158.
  • Pillai S, Szekeres K, Lawrence NJ, Chellappan SP, Blanck G. Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR. Gene. 2013 Jan.512(2):403-407. Pubmedid: 23041127.
  • Perumal D, Singh S, Yoder SJ, Bloom GC, Chellappan SP. A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC. PLoS One. 2013 Feb.7(8):e43589. Pubmedid: 22952714. Pmcid: PMC3430700.
  • Trevino JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP. Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity. Mol Cancer Ther. 2013 Dec.12(12):2722-2734. Pubmedid: 24107447. Pmcid: PMC3858536.
  • Sun J, He H, Pillai S, Xiong Y, Challa S, Xu L, Chellappan S, Yang S. GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion. J Biol Chem. 2013 Dec.288(52):36971-36982. Pubmedid: 24235142. Pmcid: PMC3873555.
  • Singh S, Bora-Singhal N, Kroeger J, Laklai H, Chellappan SP. βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer. PLoS One. 2013 Aug.8(2):e55982. Pubmedid: 23418490. Pmcid: PMC3572139.
  • Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP. EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Mol Cancer. 2012 Sep.11:73. Pubmedid: 23009336. Pmcid: PMC3497614.
  • Pillai S, Chellappan S. α7 nicotinic acetylcholine receptor subunit in angiogenesis and epithelial to mesenchymal transition. Curr Drug Targets. 2012 May.13(5):671-679. Pubmedid: 22300034.
  • Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP. Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res. 2012 Jan.72(2):516-526. Pubmedid: 22086850. Pmcid: PMC3261351.
  • Davis R, Pillai S, Lawrence N, Sebti S, Chellappan SP. TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes. Cell Cycle. 2012 Jan.11(1):109-118. Pubmedid: 22185776. Pmcid: PMC3272234.
  • Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan SP. TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death Differ. 2012 Feb.19(2):274-283. Pubmedid: 21738216. Pmcid: PMC3191254.
  • Alamanda V, Singh S, Lawrence NJ, Chellappan SP. Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity. Biochem Bioph Res Co. 2012 Feb.418(1):56-61. Pubmedid: 22240023. Pmcid: PMC3273677.
  • Trevino JG, Pillai S, Kunigal S, Singh S, Fulp WJ, Centeno BA, Chellappan SP. Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia. 2012 Dec.14(12):1102-1114. Pubmedid: 23308043. Pmcid: PMC3540937.
  • Johnson JL, Pillai S, Chellappan SP. Genetic and biochemical alterations in non-small cell lung cancer. Biochem Res Int. 2012 Aug.2012:940405. Pubmedid: 22928112. Pmcid: PMC3426175.
  • Kunigal S, Ponnusamy MP, Momi N, Batra SK, Chellappan SP. Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. Mol Cancer. 2012 Apr.11:24. Pubmedid: 22537161. Pmcid: PMC3464875.
  • Singh S, Pillai S, Chellappan S. Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. J Oncol. 2011 Jul.2011:456743. Pubmedid: 21541211. Pmcid: PMC3085312.
  • Pillai S, Rizwani W, Li X, Rawal B, Nair S, Schell MJ, Bepler G, Haura E, Coppola D, Chellappan S. ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling. Mol Cell Biol. 2011 Jul.31(14):3052-3067. Pubmedid: 21606196. Pmcid: PMC3133413.
  • Singh S, Johnson J, Chellappan S. Small molecule regulators of Rb-E2F pathway as modulators of transcription. Biochim Biophys Acta. 2011 Feb.1799(10-12):788-794. Pubmedid: 20637913. Pmcid: PMC2997897.
  • Dasgupta P, Rizwani W, Pillai S, Davis R, Banerjee S, Hug K, Lloyd M, Coppola D, Haura E, Chellappan SP. ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst. 2011 Feb.103(4):317-333. Pubmedid: 21212384. Pmcid: PMC3039728.
  • Chellappan SP. The Jab1-E2F1 interaction: a matter of life and death. Cell Cycle. 2011 Dec.10(23):3996-3997. Pubmedid: 22134136.
  • Ma Y, Chen L, Wright GM, Pillai SR, Chellappan SP, Cress WD. CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. J Biol Chem. 2010 Mar.285(13):9813-9822. Pubmedid: 20106982. Pmcid: PMC2843230.
  • Pillai S, Kovacs M, Chellappan S. Regulation of vascular endothelial growth factor receptors by Rb and E2F1: role of acetylation. Cancer Res. 2010 Jun.70(12):4931-4940. Pubmedid: 20516113. Pmcid: PMC2891185.
  • Singh S, Davis R, Alamanda V, Pireddu R, Pernazza D, Sebti S, Lawrence N, Chellappan S. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Mol Cancer Ther. 2010 Dec.9(12):3330-3341. Pubmedid: 21139044. Pmcid: PMC3058238.
  • Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S. Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One. 2009 Oct.4(10):e7524. Pubmedid: 19841737. Pmcid: PMC2759510.
  • Rizwani W, Alexandrow M, Chellappan S. Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication. Cell Cycle. 2009 May.8(10):1621-1629. Pubmedid: 19377303. Pmcid: PMC2805263.
  • Dasgupta P, Rizwani W, Pillai S, Kinkade R, Kovacs M, Rastogi S, Banerjee S, Carless M, Kim E, Coppola D, Haura E, Chellappan S. Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer. 2009 Jan.124(1):36-45. Pubmedid: 18844224. Pmcid: PMC2826200.
  • Rizwani W, Chellappan SP. In vitro replication assay with mammalian cell extracts. Methods Mol Biol. 2009.523:203-216. Pubmedid: 19381937.
  • Pillai S, Chellappan SP. ChIP on chip assays: genome-wide analysis of transcription factor binding and histone modifications. Methods Mol Biol. 2009.523:341-366. Pubmedid: 19381927.
  • Pillai S, Dasgupta P, Chellappan SP. Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. Methods Mol Biol. 2009.523:323-339. Pubmedid: 19381928.
  • Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, Lawrence N, Sebti SM, Chellappan S. A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Res. 2008 May.68(10):3810-3818. Pubmedid: 18483265. Pmcid: PMC3233839.
  • Rastogi S, Banerjee S, Chellappan S, Simon G. Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Lett. 2007 Nov.257(2):244-251. Pubmedid: 17910902.
  • Joshi B, Rastogi S, Morris M, Carastro L, DeCook C, Seto E, Chellappan S. Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites. Biochem J. 2007 Jan.401(1):155-166. Pubmedid: 16918502. Pmcid: PMC1698671.
  • Delarue F, Adnane J, Joshi B, Blaskovich M, Wang D, Hawker J, BizouarnF, Ohkanda J, Zhu K, Hamilton A, Chellappan S, Sebti S. Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter. Oncogene. 2007 Feb.26(5):633-640. Pubmedid: 16909123.
  • Dasgupta P, Chellappan S. Chromatin immunoprecipitation assays: molecular analysis of chromatin modification and gene regulation. Methods Mol Biol. 2007.383:135-152. Pubmedid: 18217683.
  • Dasgupta P, Chellappan S. Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle. 2006 Oct.5(20):2324-2328. Pubmedid: 17102610.
  • Dasgupta P, Padmanabhan J, Chellappan S. Rb function in the apoptosis and senescence of non-neuronal and neuronal cells: role in oncogenesis. Curr Mol Med. 2006 Nov.6(7):719-729. Pubmedid: 17100598.
  • Rastogi S, Joshi B, Dasgupta P, Morris M, Wright K, Chellappan S. Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol. 2006 Jun.26(11):4161-4171. Pubmedid: 16705168. Pmcid: PMC1489107.
  • Peng X, Mehta R, Wang S, Chellappan S, Mehta RG. Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells. Cancer Res. 2006 Jul.66(14):7361-7369. Pubmedid: 16849588.
  • Rastogi S, Joshi B, Fusaro G, Chellappan S. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism. J Biol Chem. 2006 Feb.281(5):2951-2959. Pubmedid: 16319068.
  • Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S. Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest. 2006 Aug.116(8):2208-2217. Pubmedid: 16862215. Pmcid: PMC1513051.
  • Dasgupta P, Kinkade R, Joshi B, Decook C, Haura E, Chellappan S. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc Natl Acad Sci U S A. 2006 Apr.103(16):6332-6337. Pubmedid: 16601104. Pmcid: PMC1458878.
  • Niesen MI, Osborne AR, Yang H, Rastogi S, Chellappan S, Cheng JQ, Boss JM, Blanck G. Activation of a methylated promoter mediated by a sequence-specific DNA-binding protein, RFX. J Biol Chem. 2005 Nov.280(47):38914-38922. Pubmedid: 16166088.
  • Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene. 2005 Mar.24(13):2204-2217. Pubmedid: 15735762.
  • Liu DX, Nath N, Chellappan SP, Greene LA. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Gene Dev. 2005 Mar.19(6):719-732. Pubmedid: 15769944. Pmcid: PMC1065725.
  • Haura EB, Cress WD, Chellappan S, Zheng Z, Bepler G. Antiapoptotic signaling pathways in non-small-cell lung cancer: biology and therapeutic strategies. Clin Lung Cancer. 2004 Sep.6(2):113-122. Pubmedid: 15476597.
  • Dasgupta P, Betts V, Rastogi S, Joshi B, Morris M, Brennan B, Ordonez-Ercan D, Chellappan S. Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery. J Biol Chem. 2004 Sep.279(37):38762-38769. Pubmedid: 15210709.
  • Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, Sebti SM, Chellappan SP. Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol. 2004 Nov.24(21):9527-9541. Pubmedid: 15485920. Pmcid: PMC522224.
  • Nath N, Wang S, Betts V, Knudsen E, Chellappan S. Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases. Oncogene. 2003 Sep.22(38):5986-5994. Pubmedid: 12955077.
  • Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem. 2003 Nov.278(48):47853-47861. Pubmedid: 14500729.
  • Joshi B, Ko D, Ordonez-Ercan D, Chellappan S. A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem Bioph Res Co. 2003 Dec.312(2):459-466. Pubmedid: 14637159.
  • Fusaro G, Wang S, Chellappan S. Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis. Oncogene. 2002 Jul.21(29):4539-4548. Pubmedid: 12085232.
  • Rosato RR, Almenara JA, Cartee L, Betts V, Chellappan SP, Grant S. The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells. Mol Cancer Ther. 2002 Feb.1(4):253-266. Pubmedid: 12467221.
  • Wang S, Fusaro G, Padmanabhan J, Chellappan SP. Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene. 2002 Dec.21(55):8388-8396. Pubmedid: 12466959.
  • Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala HM, Dent P, Grant S. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells. Cancer Res. 2001 Mar.61(6):2583-2591. Pubmedid: 11289135.
  • Chellappan SP. HOG on the promoter: regulation of the osmotic stress response. Sci Stke. 2001 Jul.2001(93):pe1. Pubmedid: 11752666.
  • Gewirtz D, Di Y, Randolph J, Jain P, Valerie K, Bullock S, Nath N, Chellappan S. Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol. Arch Biochem Biophys. 2001 Apr.388(2):243-252. Pubmedid: 11368161.
  • Nath N, Bian H, Reed EF, Chellappan SP. HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J Immunol. 1999 May.162(9):5351-5358. Pubmedid: 10228011.
  • Vrana JA, Saunders AM, Chellappan SP, Grant S. Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937). Differentiation. 1998 May.63(1):33-42. Pubmedid: 9615391.
  • Chellappan SP, Giordano A, Fisher PB. Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development. Curr Top Microbiol. 1998 Mar.227:57-103. Pubmedid: 9479826.
  • Strom DK, Cleveland JL, Chellappan S, Nip J, Hiebert SW. E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation. Cell Growth Differ. 1998 Jan.9(1):59-69. Pubmedid: 9438389.
  • Wang S, Ghosh RN, Chellappan SP. Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol Cell Biol. 1998 Dec.18(12):7487-7498. Pubmedid: 9819434. Pmcid: PMC109329.
  • Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Chellappan SP, Fisher PB, Grant S. Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia. 1997 Apr.11(4):504-513. Pubmedid: 9096690.
  • Schwarz JK, Devoto SH, Smith EJ, Chellappan SP, Jakoi L, Nevins JR. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. Embo J. 1993 Mar.12(3):1013-1020. Pubmedid: 8458319. Pmcid: PMC413302.
  • Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR. The E2F transcription factor is a cellular target for the RB protein. Cell. 1991 Jun.65(6):1053-1061. Pubmedid: 1828392.
  • Chellappan SP, Nevins JR. DNA octamer element can confer E1A trans-activation, and adenovirus infection results in a stimulation of the DNA-binding activity of OTF-1/NFIII factor. Proc Natl Acad Sci U S A. 1990 Aug.87(15):5878-5882. Pubmedid: 2143023. Pmcid: PMC54432.
  • Davis RK, Chellappan S. Disrupting the Rb-Raf-1 interaction: a potential therapeutic target for cancer. Drug News Perspect. 21(6):331-335. Pubmedid: 18836591. Pmcid: PMC2800199.


Title: ACS-IRG
Sponsor: Amer Cancer Society
PI: Chellappan, S.